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[24] However, they do warn of gastrointestinal side effects, including nausea, vomiting, diarrhea, abdominal pain, and constipation. [25] The warnings for drugs manufactured by Eli Lilly, namely, Trulicity and Mounjaro, warn of gastroparesis and other severe gastrointestinal reactions

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Rapidly increasing the dosage bypasses the natural desensitisation of GLP-1 receptors in the brain and gut, which often leads to avoidable episodes of vomiting or severe reflux