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Moreover, the complex Gel/(REG NG/LY) is formed by TGF- inhibitor LY3200882 (LY) encapsulated in ROS-responsive nanogels and homogeneously dispersed with regorafenib (REG) in a thermosensitive hydrogel can not only reduce the recruitment of TAMs and MDSCs and promote macrophages polarization from M2 to M1, but also increase the infiltration of CD8 + T cells into tumors thereby effectively inhibiting tumor growth and metastasis (213)

While AOD-9604 is not FDA-approved as a prescription drug, it has received GRAS (Generally Recognized as Safe) status, indicating low toxicity and a good safety profile

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Tirzepatide studies have shown even more promising results

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Additionally, it is now known that pro-inflammatory cytokines also hijack IGF-1 intracellular signalling by phosphorylating serine residues on insulin related substrate (IRS) molecules and hence impeding their binding to IGF-1R [124]