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Data selection criteria The literature search was screened independently by two authors

To validate the TRPV1 binding site, we performed single-channel recordings from cells expressing human TRPV1 channels

[1], and should not be extrapolated to structurally distinct triagonists such as SAR441255 [36] or LY3437943 [37], which may differ in receptor bias, potency and in vivo efficacy

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