Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy
Higher doses may be considered under clinical supervision for those who decline injections despite malabsorption, though this is an off-label approach
J Pharmacol Exp Ther 1973;187:185-94
Collagen Deposition Comparative Data: Research comparing GHK-Cu to other skin-active ingredients found that the peptide produced a 70% increase in collagen deposition over 30 days, compared to 50% for vitamin C and 40% for tretinoin (retinoic acid) in equivalent formulations
The result is an eye cream that works whether the dark circles are pigmentation-driven, vascular-driven, or both, which is how most dark circles present in practice
If you stop skin booster injections entirely and abandon post-care habits like sunscreen use, your skin may return toward its pre-treatment tone over time, especially with continued sun exposure or pollution