[5] [6] Some agents in this class (including liraglutide, semaglutide and dulaglutide) have demonstrated cardiovascular benefits in clinical trials, though specific benefits vary by individual medication
Nathan, S
Neither tells the whole story
GLP-1 medications work by: Slowing stomach emptying, so you feel full longer Suppressing hunger signals in the brain Increasing insulin release and reducing blood sugar spikes Reducing glucagon, a hormone that raises blood sugar This helps patients lose weight naturally while maintaining balanced blood sugar levels
First week: Mild nausea, fatigue, or headaches are most common Weeks 24: Symptoms often lessen as the body adapts After one month: Many people report minimal or no ongoing side effects Side effects may briefly return after dose increases, then improve again
A patient with significant constipation, reflux, a history of gallbladder issues, diabetes medication interactions, dehydration risk, or inadequate protein intake may need a different strategy than a patient whose main concern is appetite control
