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The progressive nature of comorbidity resolution, with continued improvements beyond the period of maximum WL, indicates that mechanisms beyond adiposity reduction contribute to these benefits

It also supports important cellular repair processes and activates proteins called sirtuins, which are involved in healthy aging, DNA repair, and cellular regeneration

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These standards emphasize personalized nutrition, medication safety, and cardiometabolic risk management

As more trials emerge in the future showing the effect of discontinuation of OMMs on weight and obesity-related complications, the extent of weight regain and worsening of clinical outcomes will become clearer 60