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This occurs when bile acids are not adequately reabsorbed in the terminal ileum and reach the colon, where they stimulate fluid secretion

Every manufactured lot is accompanied by batch-specific analytical documentation including: third-party reverse-phase HPLC chromatogram, ESI-MS deconvoluted mass spectrum, chiral HPLC confirming 99.5% enantiomeric excess of the (R)-isomer, polarimetric specific rotation measurement, residual moisture (loss on drying), residue on ignition, and heavy-metals quantification

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Based on the CVOTs, the treatment algorithm of T2D has changed to include GLP-1RAs independent of glycaemia in patients with established CVD or high-risk (96)

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The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohort