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Upon binding to G-protein-coupled receptors on the beta cells, intracellular cAMP level is elevated and the protein kinases, Epac1 and 2, are activated, which leads to an increase of insulin secretion

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The Outcome Reduction with Initial Glargine Intervention trial (i.e., ORIGIN) was an open-label, randomized, 12,537 patient study that compared LANTUS to standard care on the time to first occurrence of a major adverse cardiovascular event (MACE)

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