Adems de supresin de apetito (efecto central GLP-1R), tirzepatida incrementa termognesis en tejido adiposo pardo va GIPR, mejora composicin corporal preservando masa magra relativa, y modula adipocitos blancos reduciendo lipognesis
Preventive measures include staying hydrated, practicing good hygiene, and regularly monitoring for early signs of infection
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Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML et al (2011) Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial