Stress, alcohol, pollution, and aging burn through it faster than you make it, which is where topping it up comes in
31 Exposure to environmental pollutants/toxins
Mesalazine: a novel therapeutic agent for periodontitis via regulation of periodontal microbiota and inhibiting Porphyromonas gingivalis
Oxidative stress plays a significant role in the pathogenesis of GO and GD (the balance between oxidants and antioxidants is disturbed in favor of ROS), and an antioxidant approach is proposed for treatment (85, 86)
Elnaggar A, Tsombou FM, Hussain MI, Almehdi AM, Abideen Z, Yong JWH, et al
The fundamental mechanism is the activation of phase II detoxification enzymes or antioxidase controlled by Nrf2/ARE, including the expression of NAD(P)H quinone dehydrogenase 1 (NQO1), GPX, and superoxide dismutase (SOD) (Truong et al., 2014)