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Recent results involving over 2000 patients indicate that a 20-week dose-escalation period followed by a 52-week treatment with three tirzepatide doses (5, 10 and 15 mg) led to striking body weight reductions in obese patients (Table 1) [44]

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IR affects metabolic homeostasis by increasing DNL in the liver and decreasing the ability of adipose tissues to suppress lipolysis

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The standard rotation protocol divides the abdomen into four quadrants: upper-right, upper-left, lower-right, lower-left (staying at least 2 inches away from the navel)