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Tissue zinc levels are decreased in patients with cirrhosis and hepatic encephalopathy, though trials of zinc supplementation have had conflicting results (Amodio 2013)

In a retrospective cohort study of patients with type 2 diabetes, coadministration with serotonergic antidepressants (eg, citalopram/escitalopram) was associated with attenuation of the weight loss effects of GLP-1 agonists

Active targeting is achieved by adding a ligand specific to overexpressed substances on the cell surface or intracellular surface of the targeted cell to the surface of the vector

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