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Horm Res 65(suppl 4):180 Guevara-Aguirre J, Vasconez O, Martinez V, Martinez AL, Rosenbloom AL, Diamond FB Jr, Gargosky SE, Nonoshita L, Rosenfeld RG (1995) A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency

This evidence suggests that DPP-4 may play a significant role in regulating bone health and inflammatory response [2, 5, 6, 8,9,10]

In addition, in preclinical stages, a combination of GLP-1R agonism with N-methyl-D-aspartate (NMDA) receptor antagonism (GLP-1-MK-801) has been developed [115]

Methodology The review targeted the synthesis of randomized controlled trial (RCT) evidence, real-life effectiveness, cost, coverage, and policy analyses applicable to the GLP-1 receptor agonist and newer incretin-based weight management compounds

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Additionally, side effects of GLP-1 medications include vomiting