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The immunometabolic mechanisms of curcumin suggest that benefit would be concentrated in the former subgroup, and stratified trial designs testing this hypothesis would generate actionable responder profiles

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Molecular Cancer Therapeutics

& Myers, M

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(2025) reported that deleting pyruvate carboxylase (PC) in renal tubular epithelial cells destabilizes SQOR, leading to its excessive ubiquitination by E3 ligases and proteasomal degradation