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These are transformative numbers by the historical standards of pharmacological obesity treatment, where prior-generation agents rarely exceeded 5% placebo-adjusted efficacy

ECM-based biomarkers reflecting MMP-9 activity, such as C3M (MMP-9 mediated degradation of type III collagen) and C4M (MP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in Hurley stages II and III of HS and show a moderate-strong correlation with the IHS score, indicating their utility in assessing disease activity and severity [104] (Table 1, Fig

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During these check-ins, we: Track your progress Adjust your plan if needed Encourage you when you feel low If you face a setback, we guide you on how to recover instead of giving up