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Although not the focus of this review, it is noteworthy to mention the existence of other blood-brain/cerebrospinal fluid barriers that are essential for brain homeostasis

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The latter heavily rely on NAD + to support mitochondrial health, antioxidant defense, and metabolic balance

[180] reported that TNF- and IL-6 levels were decreased in AR guinea pig serum or tissues following astragalus polysaccharide (APS) treatment

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Similarly, it was discovered that the intestinal microbiota contributes significantly to human health through its regulation of body constitution, weight management, and diabetes prevention [3234]