Effectiveness of oral B12 sprays To address B12 deficiency, doctors often prescribe supplements to be taken by varying routes, including oral sprays
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2 Materials and methods 2.1 Study design This study was a multi-center, prospective, double-blind, randomized clinical trial aimed to assess the absorption rate and hence bioavailibility of an innovative oral Sucrosomial B12 (Sidevit B12 developed by Pharmanutra S.p.A, Pisa, Italy) in enhancing circulatory B12 levels in healthy deficient adults, compared to various conventional oral B12 supplement formulations, selected randomly from local pharmacies at each participating center
Kolovrat et al., 2020
The trial involved 203 obese individuals who were randomly assigned to receive Tesofensine at doses of 0.25 mg, 0.5 mg, 1.0 mg, or a placebo daily for 24 weeks
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