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In addition, exenatide was shown to activate GLP-1R and inhibit the PI3K/AKT pathway to inhibit the growth, migration, and invasion of ovarian cancer cells, and promote cell apoptosis, thereby producing anticancer effects on diabetic patients with ovarian cancer (218)

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They also monitor downstream adenylate cyclase activation and the subsequent intracellular cyclic AMP (cAMP) signaling cascades within cellular cultures