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Even though we have yet to generate any specific data to support this statement, with our previous study [7] we did show that in response to a single bout of resistance exercise, the plasma NO metabolites, nitrate and nitrite, and cGMP were elevated 30 min following exercise when taking GSH + CIT

8,9 Acute stress stimulates glutamate release in the prefrontal cortex and hippocampus

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56 Therefore, BDNF reduction in the vSUB can cause deficits in reward function and induce anhedonia

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The reaction mixtures were then centrifuged for 5 min at 6000 g and the supernatants assayed for DNA oxidation with an 8-hydroxy-2-deoxyguanosine (8-OHdG) ELISA assay (Cell Biolabs, CA, USA)