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Psychiatry Clin Neurosci (2014) 68(9):692700

This neuroinflammatory response was accompanied by reduced expression of tight junction proteins in the BBB, suggesting that systemic inflammation originating from the gut directly impacts BBB permeability and brain inflammation

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Realistic timelines matter: expect initial brightening within 4-8 weeks , with significant dark spot fading around 3-4 months as pigmented cells shed through multiple turnover cycles

At 12 mg, 100% of participants lost at least 5% of body weight and 83% lost at least 15%

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