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Gut microbiome and kidney stone disease: not just an Oxalobacter story

10.1080/01490450490506201 4 AmachiS.KawaguchiN.MuramatsuY.TsuchiyaS.WatanabeY.ShinoyamaH.et al (2007)

NAD+'s metabolic roles encompass several key pathways: Energy production : NAD+ regulates glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and fatty acid oxidation by functioning as a cofactor for redox reactions Redox balance : The NAD+/NADH ratio controls flux through metabolic pathways, ensuring properly regulated cellular metabolism Mitochondrial function : NAD+ is essential for ATP synthesis through oxidative phosphorylation, where NADH donates electrons to complex I in the electron transport chain Biosynthetic processes : Through its phosphorylated form NADP+, it supports anabolic reactions and cellular antioxidant defense mechanisms NAD+ directly shapes cellular processes that maintain tissue homeostasis

BEYRATH J, PELLEGRINI M, RENKEMA H, et al

doi: 10.1708/3301.32713, 32 Cintrn-ColnA

The study appears online in the journal Nature Communications