That is why the protocol uses once-weekly dosing
Aroda VR, Blonde L, Pratley RE
In contrast, Noom states that their dosing starts at 25% or less of the standard 0.25 mg dose and escalates at a personalized rate. While microdosing GLP-1 medications may provide a more personalized experience, there are still questions regarding the safety of this practice as there are currently no published studies on the process, and the microdoses may come from a compounding pharmacy
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Since the medication causes glucose-dependent insulin release and did not cause hypoglycemia but suppressed appetite, liraglutide and semaglutide were both approved for weight loss in patients without diabetes [33, 34]
Retatrutide takes this further