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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]

It will also be important to understand how lifespan changes in the stem cell environment may impact NRF2s intrinsic control of stem cell function

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