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Exposure to extreme temperatures can affect the medication's potency and make it less effective

The crop yield component and productivity significantly declined due to Pb toxicity in different rice genotypes [21], where yield reduction was 46.27% to 69.12%

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10.1021/tx500284g 44 LedentP.DuezC.VanhoveM.LejeuneA.Fonz,E.CharlierP.et al

The most common side effect involves gastrointestinal symptoms, particularly nausea and constipation during initial GLP-1 dose escalation, though metformin's typical diarrhea effect sometimes partially offsets this