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Update on melasmaPart I: pathogenesis

Among the essential AAs, methionine (Met) is the most limiting nutrient, especially in dairy cattle diets

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The greater amount of L-carnitine there is in the tissue, the greater amount of fat that can be burnt

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R Methylation: SAM-dependent methyltransferases catalyze the SN2 transfer of the methyl group from the sulfonium center of SAM-e to an electron-rich acceptor atom (O, N, or S) on the substrate, producing the methylated product and SAH