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Expert Tip: Avoid the waistline area where your pants or belt might rub against the injection site, as this can cause irritation later in the day

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Fisman, E

GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days

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If you have successfully used nighttime injection at lower doses, you can continue, but extend your buffer before lying down to a full 3 hours minimum