Thus, rather than representing a distinct subtype of SAGE-DM, MACS may be best conceptualized as a frequent, age-associated endocrine modifier that can either act as an independent cause of diabetes or interact synergistically with aging-related metabolic vulnerability to promote the SAGE-DM phenotype
Diabetic Retinopathy Complications: In a 2-year trial involving patients with type 2 diabetes and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with Ozempic (3.0%) compared with placebo (1.8%)
Ralph DJ, Brooks MD, Bottazzo GF et al: The treatment of Peyronie's disease with tamoxifen
In another study, chronic GLP1-S treatment in rodent models produced sustained weight loss, primarily by shrinking meal size rather than reducing the number of meals
Although not definitively proven, this risk has been a significant concern, particularly with long-term use
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