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44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment

CJC-1295 was engineered with modifications that extend it to days either through a DAC (Drug Affinity Complex) modification that enables albumin binding, or without DAC for a shorter but still extended duration

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Depending on the situation, doctors may also check kidney and liver function, blood sugar, creatine kinase, ammonia, or markers of metabolic disease

Shah, M., Awad, A