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doi: 10.3390/molecules25225474 92 LiMPengYChenWGaoYYangMLiJet al

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The majority of the reported events occurred in patients who had experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6.1)]

Clinical investigations of Pycnogenol supplementation for twelve weeks in women aged 55 to 68 years found increased hyaluronic acid synthase mRNA levels by 44% and collagen type 1 mRNA levels by 40% in skin biopsies ( on skin hydration and elasticity