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Switching is possible but should only be done under a healthcare providers supervision

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Reducing dose of insulin secretagogue or insulin may be necessary Acute Kidney Injury: Monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions Hypersensitivity Reactions: Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported

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Lawrence and Burk subsequently modified this protocol for specialized applications, including the assessment of GPx activity in liver supernatants from selenium-deficient experimental models [22]