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suggested that CFS may be a stress related disorder and hypothesized that an initial stress may cause an increase in corticotropin release hormone (CRH) with a consequent downstream regulation of CRH receptors on pituitary corticotrophs neurons (Scott et al

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Cyclic adenosine monophosphate (cAMP) levels activate protein kinase A, resulting in phosphorylation and activation of SIRT1 (Wan et al., 2016)

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