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In 2003, a clinical trial demonstrating prolonged survival of patients with metastatic colorectal cancer when chemotherapy was administrated in combination with humanized neutralizing antibodies targeting anti-vascular endothelial growth factor (VEGF) resulted in an FDA approval and provided proof-of-concept that anti-angiogenic therapy can be successfully used to treat cancer [4]

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Just look at this figure at the website of the organization MitoAction: B12 deficiency usually affects like mitochondrial disorders many organ systems, especially the various parts of the nervous system