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This theory faces challenges in explaining the diverse pathological features, shows a weak correlation between A and cognitive decline, and has failed to demonstrate efficacy in numerous clinical drugs to target A

It is a reminder that neither form has an established human safety profile

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Across multiple animal studies, commonly scaled ranges often cluster between 1 and 4 mcg per kilogram, with higher experimental rodent models occasionally translating closer to 57 mcg per kilogram

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Metformin also has modest effects on weight, typically resulting in small reductions or weight stabilisation rather than significant loss