During the first weeks or months, some people unintentionally under-eat as their body adjusts
Under certain conditions, PI3K/Akt is also activated as it supports neuronal energy regulation, synaptic function, antioxidant defense, and autophagy (Mller et al., 2019
Pinkus H
Acknowledgements We thank Julie Dam and Erika Cecon (Institut Cochin, France) for their valuable expert advice during the preparation of the manuscript
This behavior is in accordance, although not necessarily in a causal relationship, with the higher reduction potential of glutathione
However, this will need to be considered in the context of data from cardiovascular and kidney outcome trials involving tirzepatide