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These transporters are responsible for effluxing cytotoxins out of the tumor cells, thus compromising efficacy
The city of Charlotte received funding from the Works Progress Administration (WPA) to build an airport with three runways, a terminal, a hangar, and a control tower
Once reconstituted, keep refrigerated (28C) and use within roughly 34 weeks
In a 2015 trial, oral tofacitinib was superior to placebo and as safe and effective as etanercept, one of the most widely used injectable biologics, for the treatment of moderate-to-severe plaque psoriasis
This leads to the release and subsequent cytoplasmic translocation of p53, which in turn activates a transcription-independent pro-apoptotic pathway, facilitating the selective clearance of senescent cells (Kong et al., 2025
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