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The available experimental evidence, which is not yet definitive, proposes several distinct mechanisms that manifest tumor rescue pathways to anti-angiogenic therapies

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Research along these lines also tends to suggest that the peptide may interact with the NO-system [nitric oxide system] , providing endothelium protection and angiogenic effect, even in severely impaired conditions

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doi: 10.1111/imm.13443 89 MoritaSTakagiTInabaHFurukawaYKishimotoSUrakiSet al

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