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Melasma develops due to several factors: Hormonal changes (pregnancy, oral contraceptives) Genetic predisposition Skin inflammation or irritation Certain medications Cosmetic products Heat and UV exposure Excessive sun exposure Sun exposure remains the strongest trigger , making sunscreen essential in treatment

This process occurs mainly in the liver, where glutathione helps protect liver cells from damage and supports overall liver function

Therapeutic drug monitoring should facilitate the design of proper dosing regimens to prevent toxicity

Liver-specific knockout of ACC1 decreased hepatic lipid accumulation in mice and DNL in hepatocytes [58]

Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers

2024) expression were proposed as contributing to the wound-healing proficiency of AC