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How does retatrutide compare to tirzepatide in Phase 2 data

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Risk-of-bias assessment The methodological quality of included RCTs was assessed utilizing the Cochrane Risk of Bias 2 (RoB2) tool [18], while observational studies were evaluated with the Risk Of Bias In Non-randomized Studiesof Interventions (ROBINS-I) [19]

Results: The analysis of 2,313 pancreatitis reports linked to hypoglycemic agents revealed a predominant association with GLP-1 RA (70.2%) compared to DPP-4 inhibitors (15%) and SGLT2 (14.7%)

It emphasises how GHRP-2 activates the ghrelin receptor to increase the production of growth hormone, which improves lipolysis and energy use

Study characteristics The main characteristics of included studies are summarized in Supplementary Table 1