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Dysregulation in the FXR and TGR5 signaling pathways leads to hepatocyte toxicity due to an increase in primary bile acids like cholic acid (CA) and chenodeoxycholic acid (CDCA), as well as a decrease in secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA), which in turn triggers microbiota dysbiosis and MASLD pathogenesis [249]

Advanced trainee + already lean Starting point: 5+ years serious training, 10-15% body fat, near genetic potential 6-month realistic transformation: Build 2-4 pounds muscle (very slow) Lose 5-10 pounds fat (getting very lean) Net weight: down 3-6 pounds Subtle refinement, not dramatic transformation Why subtle: Close to genetic limits for muscle

Remember that you are unlikely to experience all side effects that are listed, and you may not experience any at all

Yim, J., Park, J., Kim, G., Jo, A

Biochim Biophys Acta (BBA)-General Subj