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As use of GLP-1 receptor agonists continues to expand, the integration of conventional clinical evidence with large-scale observational data may offer a more complete picture of how these therapies affect patients in routine practice

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For example, Bifidobacterium promote the proliferation of beneficial commensals and inhibit the growth of pathogenic bacteria, thereby improving intestinal barrier function and nutrient absorption efficiency (Li et al., 2025)

The anti-proliferative effect was found to be due to the arrest of cells in S/G2-M phase of cell cycle, with increased fraction of apoptotic cells

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TABLE 7 Eggers test and trim-and-fill analysis