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There is also some evidence that these drugs can alter the gut microbiome (the community of bacteria in your intestines), which might have subtle effects on nutrient metabolism

56 An example of this is the neuronal Ca 2+ sensor-I (NCS-1), which interacts with D 2

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Prolonged GLP-1RAs therapy may exacerbate existing chronic inflammation in patients with T2DM, thereby potentially elevating their risk of pancreatic cancer