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Hypoxia upregulated oxygen-sensing, metabolic, and HIF-1 pathways and downregulated Hippo signaling

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Nevertheless, redox cycling remains an understated mechanism of toxicity due to the fleeting existence of free radical intermediates which hinders their quantification in real time, both in vitro and in vivo 6

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In the pre-equilibrium stage, the system was gradually heated to 300 K using 200 ps in the NVT ensemble and 200 ps in the NPT ensemble at 1 atm