206,347 In another study, treatment of primary mouse chondrocytes with liraglutide reduced the mRNA expression levels of iNOS, MMP-13, and ADAMTS5, leading to a decrease in the secretion of inflammatory markers, including NO, prostaglandin E, and IL-6
Helmstdter J, Keppeler K, Kster L, Mnzel T, Daiber A, Steven S (2022) Glucagon- like peptide-1 (GLP-1) receptor agonists and their cardiovascular benefits-The role of the GLP-1 receptor
As a starting point, we used the HbA1C 12 months before the decision point, which is typically available in clinical practice
Surprisingly, GLP-1RAs, such as liraglutide, lixisenatide, and semaglutide, have showed outstandingly neuroprotective effects on animal models of PD (63, 64)
According to Alkhaddo, even though these oral agents may not be as effective as GLP-1s, they may be a good choice to help patients maintain their weight
[Read More] Harder H, Nielsen L, Tu DT, Astrup A