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It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants

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Unfortunately, these efforts are being thwarted by the new guidelines, encouraging broader use of incretin mimetics in overweight patients, particularly those at high cardiovascular risk