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Contraindications Absolute contraindications include Wilsons Disease or other copper metabolism disorders, known copper allergy or hypersensitivity, and pregnancy or breastfeeding (no safety data exists for systemic use during these periods)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Palaiogeorgou A.M., Papakonstantinou E., Golfinopoulou R., Sigala M., Mitsis T., Papageorgiou L., Diakou I., Pierouli K., Dragoumani K., Spandidos D.A., et al

No wasting half the ampoule and we are both getting the B12 we need, although he has shown so much cognitive improvement that I am thinking maybe be should up his dose/frequency

"The AAP explicitly states that drugs should not be a monotherapy