Severe impairment of mitochondrial FAO is associated with an accumulation of fatty acid derivatives such as ACs, acylglycine esters, and dicarboxylic acids in plasma and urine [82]
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The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance
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Neurol Clin 1993
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