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Using an in-house bioinformatics pipeline, we aligned sequencing data to the hg19 reference genome and filtered variants, excluding common variants (1000 Genomes), retaining only rare variants with predicted high or moderate functional impact and excluding HLA-DBR gene

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The prevalence of sarcopenic obesity dropped from 49% at baseline to 33% [51]

This systemic inflammation has been linked to an increased risk and severity of conditions, including type 2 diabetes, cardiovascular disease, and obesity

The thrombotic risk associated with oral estrogen does not appear to extend to transdermal delivery