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In a randomized clinical trial including 73 children aged between 1 and 18 years, with at least 5% skin involvement by AD, compared melatonin (3 mg/day) with placebo, both administered for a 4-week period, with a 2-week washout period

Males had a greater density of BrdU/Sox2-ir cells compared with females in the dorsal DG at 2 h but not at any other time point (a priori: p = 0.0019

While not approved for therapeutic or diagnostic use, its molecular behavior makes it a valuable tool for investigating fundamental biological processes

In vitro studies

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