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Deficiencies in zinc have been observed in some women with PCOS, and it has been hypothesized that this may contribute to the insulin-resistant phenotype of the condition

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Treatment of cells with GYY4137, an exogenous donor that releases H 2 S with slower kinetics, also inhibited both GLP-1 and PYY release (43 4% inhibition in GLP-1 release and 68 6% inhibition in PYY release with 10 mM GYY4137) (Figures 6A,B)

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