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Chem Eng J

The hydrazone linkage is relatively stable and hydrolyzes very slowly at pH 7.4 while at low pH 5-6 in endosomal/lysosomal compartments the rate of hydrolysis is increased

The proto-oncogenic transcriptional co-activator YAP is also an important factor, which can inhibit ferroptosis upregulation of multiple ferroptosis modulators, including acyl-CoA synthetase long chain family member 4 (ACSL4) and transferrin receptor [15]